| First Author | Besmer P | Year | 1986 |
| Journal | Nature | Volume | 320 |
| Issue | 6061 | Pages | 415-21 |
| PubMed ID | 3007997 | Mgi Jnum | J:8245 |
| Mgi Id | MGI:56714 | Doi | 10.1038/320415a0 |
| Citation | Besmer P, et al. (1986) A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320(6061):415-21 |
| abstractText | A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus. |
