| First Author | Nadeau JH | Year | 1986 |
| Journal | Genetics | Volume | 113 |
| Issue | 1 | Pages | 91-9 |
| PubMed ID | 3710145 | Mgi Jnum | J:8289 |
| Mgi Id | MGI:56758 | Doi | 10.1093/genetics/113.1.91 |
| Citation | Nadeau JH (1986) A glyoxalase-1 variant associated with the t-complex in house mice. Genetics 113(1):91-9 |
| abstractText | A quantitative variant of glyoxalase-1 associated with the t-complex in house mice is described. GLO-1C in red cell lysates from mice heterozygous for complementing t-haplotypes and from mice homozygous for the tw8-haplotype had less than one-third the GLO-1 activity of NZB/BlNJ, the inbred strain with the lowest activity previously reported. GLO-1C appeared to be determined by the structural locus Glo-1 and, together with two partial t6-haplotypes, was used to map Glo-1 to the telomeric portion of the t6-haplotype. Glo-1c was associated with all t-haplotypes tested and has not been found in mice that lack a t-complex. Thus, this variant of Glo-1c provides both a further example of gametic disequilibrium between the t-complex and linked loci and a readily identifiable marker for the t-complex. |
