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Publication : The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

First Author  Isobe M Year  1986
Journal  Proc Natl Acad Sci U S A Volume  83
Issue  12 Pages  4399-402
PubMed ID  3086883 Mgi Jnum  J:8310
Mgi Id  MGI:56778 Doi  10.1073/pnas.83.12.4399
Citation  Isobe M, et al. (1986) The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A 83(12):4399-402
abstractText  The surface glycoproteins T4 and T8 define functionally distinct populations of T lymphocytes. We have obtained cDNA and genomic clones encoding the T4 molecule and used these as probes to determine the chromosomal location of this gene. Genomic blotting experiments, along with in situ hybridization analyses, indicate that the T4 gene resides on the short arm of human chromosome 12, at region p12-pter. Thus, the T4 gene is not linked to any known member of the immunoglobulin gene family, including its counterpart gene, T8, which resides on human chromosome 2 immediately distal to the immunoglobulin kappa locus.
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