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Publication : Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.

First Author  Krasnewich D Year  1987
Journal  Somat Cell Mol Genet Volume  13
Issue  2 Pages  179-82
PubMed ID  3105095 Mgi Jnum  J:8658
Mgi Id  MGI:57123 Doi  10.1007/BF01534698
Citation  Krasnewich D, et al. (1987) Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5. Somat Cell Mol Genet 13(2):179-82
abstractText  The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3) and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse X Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3) to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.
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