First Author | Krasnewich D | Year | 1987 |
Journal | Somat Cell Mol Genet | Volume | 13 |
Issue | 2 | Pages | 179-82 |
PubMed ID | 3105095 | Mgi Jnum | J:8658 |
Mgi Id | MGI:57123 | Doi | 10.1007/BF01534698 |
Citation | Krasnewich D, et al. (1987) Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5. Somat Cell Mol Genet 13(2):179-82 |
abstractText | The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3) and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse X Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3) to mouse chromosome 5 and suggest the name as the Udpgt-3 locus. |