| First Author | Hammer MF | Year | 1987 |
| Journal | Genetics | Volume | 115 |
| Issue | 3 | Pages | 521-33 |
| PubMed ID | 3569879 | Mgi Jnum | J:8670 |
| Mgi Id | MGI:57135 | Doi | 10.1093/genetics/115.3.521 |
| Citation | Hammer MF, et al. (1987) Regulatory and structural genes for lysozymes of mice. Genetics 115(3):521-33 |
| abstractText | The molecular and genetic basis of large differences in the concentration of P lysozyme in the small intestine has been investigated by crossing inbred strains of two species of house mouse (genus Mus). The concentration of P in domesticus is about 130-fold higher than in castaneus. An autosomal genetic element determining the concentration of P has been identified and named the P lysozyme regulator, Lzp-r. The level of P in interspecific hybrids (domesticus X castaneus) as well as in certain classes of backcross progeny is intermediate relative to parental levels, which shows that the two alleles of Lzp-r are inherited additively. There are two forms of P lysozyme in the intestine of the interspecific hybrid--one having the heat stability of domesticus P, the other being more stable and presumably the product of the castaneus P locus. These two forms occur in equal amounts, and it appears that Lzp-r acts in trans. The linkage of Lzp-r to three structural genes (Lzp-s, Lzm-sl, and Lzm-s2), one specifying P lysozyme and two specifying M lysozymes, was shown by electrophoretic analysis of backcrosses involving domesticus and castaneus and also domesticus and spretus. The role of regulatory mutations in evolution is discussed in light of these results. |
