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Publication : A new V gene expressed in lambda-2 light chains of the mouse.

First Author  Dildrop R Year  1987
Journal  Eur J Immunol Volume  17
Issue  5 Pages  731-4
PubMed ID  3034625 Mgi Jnum  J:8717
Mgi Id  MGI:57182 Doi  10.1002/eji.1830170525
Citation  Dildrop R, et al. (1987) A new V gene expressed in lambda-2 light chains of the mouse. Eur J Immunol 17(5):731-4
abstractText  We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.
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