| First Author | Palmer MJ | Year | 1987 |
| Journal | J Exp Med | Volume | 166 |
| Issue | 1 | Pages | 95-108 |
| PubMed ID | 2439640 | Mgi Jnum | J:32470 |
| Mgi Id | MGI:79966 | Doi | 10.1084/jem.166.1.95 |
| Citation | Palmer MJ, et al. (1987) Widespread transcription of a Qa region gene in adult mice. J Exp Med 166(1):95-108 |
| abstractText | The mouse MHC class I family includes genes encoded in four regions: H-2K, H-2D, Qa and Tla. While K/D genes are well characterized, relatively little is known about Qa or Tla genes. We have studied the transcription of a B10.P Qa region gene. DNA sequence comparisons of the transmembrane region, supported by Southern blot analysis of cosmid and genomic DNAs from BALB/c and C57BL/10, demonstrate the lambda 3a gene corresponds to Q4p. In both Northern blots and RNA protection experiments using probes derived from the 3' noncoding region, we found that Q4, like the H-2K and H-2D genes, is widely transcribed in B10.P tissues. These data demonstrate for the first time widespread transcription of a Qa gene. |
