First Author | Avner P | Year | 1987 |
Journal | Somat Cell Mol Genet | Volume | 13 |
Issue | 3 | Pages | 267-72 |
PubMed ID | 3299748 | Mgi Jnum | J:8788 |
Mgi Id | MGI:57253 | Doi | 10.1007/BF01535208 |
Citation | Avner P, et al. (1987) A-raf oncogene localizes on mouse X chromosome to region some 10-17 centimorgans proximal to hypoxanthine phosphoribosyltransferase gene. Somat Cell Mol Genet 13(3):267-72 |
abstractText | The localization of the A-raf cellular oncogene on the mouse X chromosome has been determined using Xbal-restricted DNAs prepared from progeny of an interspecies backcross between the B6.CBA.R1 and the Spe/Pas mouse strains. This localization to the proximal part of the mouse X chromosome has been confirmed by the use of somatic cell hybrids, carrying partially deleted X chromosomes and suggests that the A-raf oncogene localizes to a region lying some 10-17 centimorgans proximal to the hypoxanthine phosphoribosyltransferase (Hprt) gene between the locus DXPas4 and the locus DXPas7 defined by the cross-reacting human X chromosome-specific probe DXS32 (M2C). This localization on the mouse X chromosome is compatible with the presence of the A-raf oncogene on the short arm of the human X chromosome between the centromere and Xp21. |