First Author | Thompson CC | Year | 1987 |
Journal | Science | Volume | 237 |
Issue | 4822 | Pages | 1610-4 |
PubMed ID | 3629259 | Mgi Jnum | J:32476 |
Mgi Id | MGI:79972 | Doi | 10.1126/science.3629259 |
Citation | Thompson CC, et al. (1987) Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. Science 237(4822):1610-4 |
abstractText | A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system. |