First Author | Sakaizumi M | Year | 1988 |
Journal | Immunogenetics | Volume | 27 |
Issue | 1 | Pages | 57-60 |
PubMed ID | 3334724 | Mgi Jnum | J:8929 |
Mgi Id | MGI:57394 | Doi | 10.1007/BF00404445 |
Citation | Sakaizumi M, et al. (1988) The locus controlling liver GM1(NeuGc) expression is mapped 1 cM centromeric to H-2K. Immunogenetics 27(1):57-60 |
abstractText | The polymorphic variation of liver GM1 (NeuGc) ganglioside was found in inbred strains of the mouse. The genetic analysis using C57BL/10 (GM1-negative) and SWR (GM1-positive) mice revealed that a single autosomal gene (Ggm-1) was involved in the expression of liver GM1(NeuGc) and that C57BL/10 mice lacking GM1(NeuGc) expression carried a defective gene on Ggm-1. Since our previous study on H-2 congenic mice indicated that Ggm-1 was linked to the H-2 complex, in this study we measured recombination frequencies among Ggm-1, Glo-1 and H-2K in the backcross progeny between (C57BL/10 X SWR)F1 and C57BL/10. Ggm-1 was mapped 1 cM centromeric to H-2K on chromosome 17. |