| First Author | Mayer BJ | Year | 1988 |
| Journal | Nature | Volume | 332 |
| Issue | 6161 | Pages | 272-5 |
| PubMed ID | 2450282 | Mgi Jnum | J:19716 |
| Mgi Id | MGI:67855 | Doi | 10.1038/332272a0 |
| Citation | Mayer BJ, et al. (1988) A novel viral oncogene with structural similarity to phospholipase C. Nature 332(6161):272-5 |
| abstractText | Numerous oncogenes have been isolated from acutely transforming retroviruses. To date, the products of these viral oncogenes have been protein kinases, nuclear proteins, growth factors, or GTP-binding proteins. We have cloned the previously uncharacterized avian sarcoma virus CT10 and sequenced its genome. This virus encodes a protein, p47gag-crk, that has blocks of sequence similarity to the amino-terminal, non-catalytic region of the non-receptor class of tyrosine kinases. In addition, the structure of p47gag-crk has striking similarity to a 180-amino acid region of bovine brain phospholipase C. Biochemical data suggest that p47gag-crk activates one or several endogenous tyrosine kinases. |
