| First Author | Mansour SL | Year | 1988 |
| Journal | EMBO J | Volume | 7 |
| Issue | 7 | Pages | 2035-41 |
| PubMed ID | 3416832 | Mgi Jnum | J:9355 |
| Mgi Id | MGI:57816 | Doi | 10.1002/j.1460-2075.1988.tb03043.x |
| Citation | Mansour SL, et al. (1988) Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family. EMBO J 7(7):2035-41 |
| abstractText | Mouse embryos at 7.5 days of gestation and endodermal cells derived from embryonal carcinoma cells each express four int-2 mRNAs of similar size and relative abundance. To determine their structure and coding potential, we prepared a cDNA library from endoderm mRNA and isolated several int-2 cDNAs. Structural analysis of these cDNAs combined with Northern blot hybridization and primer extension analyses of int-2 mRNA revealed that the differences between the mRNAs are generated through the use of two alternate transcriptional start sites and two alternate polyadenylation sites. All four mRNAs share a common core sequence that encodes a protein with amino acid similarity to fibroblast growth factor. |
