| First Author | Aldrich CJ | Year | 1988 |
| Journal | Immunogenetics | Volume | 28 |
| Issue | 5 | Pages | 334-44 |
| PubMed ID | 2459056 | Mgi Jnum | J:9387 |
| Mgi Id | MGI:57848 | Doi | 10.1007/BF00364232 |
| Citation | Aldrich CJ, et al. (1988) Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm. Immunogenetics 28(5):334-44 |
| abstractText | We examined the regulation of cell surface expression of the Qa-1 alloantigens using a panel of monoclonal anti-Qa-1 cytotoxic T-lymphocyte (mCTL) lines. In contrast to previous reports of tissue-specific expression, we found that Qa-1 was widely expressed, resembling the prototypical class I H-2K/D molecules. We further found that an H-2D-linked gene, which we termed Qdm for Qa-1 determinant modifier, controlled expression of certain CTL-defined Qa-1 antigenic determinants. H-2Dk homozygous haplotypes expressed a recessive allele of the modifier, Qdmk, whereas all other H-2 haplotypes tested expressed a dominant allele, Qdm+. The Qdm+ allele regulated in trans Qa-1 epitope expression from a Qdmk chromosome, modifying expression of particular CTL-defined Qa-1 antigenic determinants rather than affecting levels of cell surface expression. Mechanisms of Qdm function may include either a novel protein modification system or an unprecedented case of antigen recognition restricted by a nonclassical major histocompatibility complex molecule. |
