| First Author | D'Eustachio P | Year | 1988 |
| Journal | J Immunol | Volume | 141 |
| Issue | 9 | Pages | 3067-71 |
| PubMed ID | 2902144 | Mgi Jnum | J:9398 |
| Mgi Id | MGI:57859 | Doi | 10.4049/jimmunol.141.9.3067 |
| Citation | D'Eustachio P, et al. (1988) The IL-4 gene maps to chromosome 11, near the gene encoding IL-3. J Immunol 141(9):3067-71 |
| abstractText | IL-4/B cell stimulatory factor 1 (IL-4) is a potent mediator of the growth and differentiation of cells of most hemopoietic lineages. IL-4 is one of a number of lymphokines produced by T cells after activation with Ag or mitogen. In order to map the chromosomal location of the IL-4 gene, Chinese hamster-mouse somatic cell hybrids were used in Southern blot analyses with an IL-4 cDNA probe. These results suggested that the IL-4 gene was located on chromosome 11. In contrast, the gene encoding IL-2 was localized to either chromosome 1 or 3. The identification of a strain-specific Bgl II restriction enzyme polymorphism in the IL-4 gene was used to map the IL-4 gene to a position on mouse chromosome 11 within 1 centimorgan of the gene encoding IL-3. |
