| First Author | Asarnow DM | Year | 1988 |
| Journal | Cell | Volume | 55 |
| Issue | 5 | Pages | 837-47 |
| PubMed ID | 2847872 | Mgi Jnum | J:37231 |
| Mgi Id | MGI:84633 | Doi | 10.1016/0092-8674(88)90139-0 |
| Citation | Asarnow DM, et al. (1988) Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell 55(5):837-47 |
| abstractText | T cells bearing gamma delta antigen receptors constitute minor populations in most peripheral lymphoid tissues but represent the major populations of T cells in certain epithelia, including the epidermis. We show that murine dendritic epidermal cell (dEC) clones express V gamma and V delta gene segments, which are rare in adult T cells but predominate in fetal thymocytes. Analysis of the junctions of the rearranged gamma and delta genes shows a striking homogeneity among the receptors of five dEC clones. Our data support a model in which dECs represent one of perhaps several waves of emigrants from the early fetal thymus, and imply a role for dECs in immune surveillance that is distinct from that of alpha beta- and other gamma delta-bearing T cells. |
