| First Author | Moreau JF | Year | 1988 |
| Journal | Nature | Volume | 336 |
| Issue | 6200 | Pages | 690-2 |
| PubMed ID | 3143918 | Mgi Jnum | J:30931 |
| Mgi Id | MGI:78214 | Doi | 10.1038/336690a0 |
| Citation | Moreau JF, et al. (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336(6200):690-2 |
| abstractText | Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type. |
