| First Author | Mucenski ML | Year | 1987 |
| Journal | Oncogene Res | Volume | 2 |
| Issue | 1 | Pages | 33-48 |
| PubMed ID | 3505665 | Mgi Jnum | J:34583 |
| Mgi Id | MGI:82038 | Citation | Mucenski ML, et al. (1987) Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strains. Oncogene Res 2(1):33-48 |
| abstractText | Lymphomas from 21 AKXD recombinant inbred mouse strains were analyzed for retrovirally induced rearrangements in seven known or putative proto-oncogene loci. Among the rearrangements detected in the 258 lymphomas screened, most rearrangements appeared to be caused by viral integration. Rearrangements were detected in the Myc, Pvt-1, Pim-1, Mlvi-1, Mlvi-2, and Fis-1 loci, but not in the Myb locus. Seven lymphomas contained rearrangements in two loci. Nearly 90% of the rearrangements were observed in T cell lymphomas; few were detected in B cell or myeloid tumors. Rearrangements in Pvt-1, Fis-1, Mlvi-1, and Mlvi-2 were identified only in T cell lymphomas. Alterations in the Myc and Pim-1 loci, although occurring predominantly in T cell lymphomas, were occasionally detected in other types of lymphoma. These data suggest that the repertoire of cellular proto-oncogenes activated by integration of virus into lymphomas may be different for each hematopoietic cell lineage. The AKXD lymphomas represent a useful resource for identifying these sites. |
