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Publication : Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice.

First Author  Fiszer-Szafarz B Year  1989
Journal  Somat Cell Mol Genet Volume  15
Issue  1 Pages  79-83
PubMed ID  2916164 Mgi Jnum  J:9611
Mgi Id  MGI:58069 Doi  10.1007/BF01534672
Citation  Fiszer-Szafarz B, et al. (1989) Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet 15(1):79-83
abstractText  Analysis of mouse serum hyaluronidase by polyacrylamide gel electrophoresis, with the substrate high-molecular-weight hyaluronan (hyaluronic acid) included in the gel performed in mice of two different strains, BALB/cBy and C57BL/6By, reveals a pattern of multiple enzyme forms specific for each genotype. In BALB/c serum, seven different forms are present, only one of which is found in C57BL/6 serum. Segregation analysis of the enzyme polymorphism in backcross progeny and in recombinant inbred and bilineal congenic lines shows that the difference is due to a single locus, which we have designated as Hyal-1. Hyal-1 is linked to the histocompatibility locus H-7, on chromosome 9.
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