| First Author | van Lohuizen M | Year | 1989 |
| Journal | EMBO J | Volume | 8 |
| Issue | 1 | Pages | 133-6 |
| PubMed ID | 2653809 | Mgi Jnum | J:9745 |
| Mgi Id | MGI:58202 | Doi | 10.1002/j.1460-2075.1989.tb03357.x |
| Citation | van Lohuizen M, et al. (1989) N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas. EMBO J 8(1):133-6 |
| abstractText | We report a new common proviral insertion site in murine leukemia virus-induced T cell lymphomas to be N-myc. Proviral activation of N-myc was found in 35% of independently induced primary tumors. The vast majority of the proviral insertions occur within a small segment of the 3'-untranslated region of the N-myc gene, directly downstream of the protein-encoding domain. This results in an increased level of expression of a truncated N-myc mRNA. Together with the previously shown c-myc activation we now find involvement of myc genes in greater than 75% of the primary T cell lymphomas induced by Moloney murine leukemia virus in C57BL10 and BALB/c mice, and show for the first time that N-myc can be over-expressed by a mechanism other than gene amplification. |
