| First Author | Bruisten SM | Year | 1989 |
| Journal | Genetics | Volume | 121 |
| Issue | 4 | Pages | 795-801 |
| PubMed ID | 2566557 | Mgi Jnum | J:9797 |
| Mgi Id | MGI:58254 | Doi | 10.1093/genetics/121.4.795 |
| Citation | Bruisten SM, et al. (1989) Haplotype-specific interactions of non-H-2-linked genetic factors controlling the mouse C4 and Slp protein levels. Genetics 121(4):795-801 |
| abstractText | The influence of non-H-2 linked genes on the plasma levels of the H-2 S-region encoded proteins C4, Slp, and factor B was tested in Recombinant Inbred (RI) strains. The A X B and B X A RI strains exhibit a continuous range of C4 and Slp levels from very high to very low which reach beyond the levels of their parental strains, C57BL/6J and A/J, indicating involvement of several trans-regulatory (non-H-2-linked) genes. Only limited variation in levels of factor B has been found. No linkage relationship could be established for the trans-regulatory genes, because more than one gene is involved. A complex interaction of H-2 haplotype, genetic background, sex, and possibly maternal effect in determining the C4 and Slp protein plasma levels has been observed. The H-2-dependent sex effect is evident, because males have higher C4 levels than females in RI strains with H-2b but not with H-2a haplotype. This sex effect is also background dependent, because it is present in the H-2b congenic strain on A background (A.BY) but not in C57BL/10 and C57BL/6 (both H-2b). Mice from RI strains with H-2b haplotype have in general higher C4 levels than mice with H-2a haplotype. |
