| First Author | Regnier DC | Year | 1989 |
| Journal | J Virol | Volume | 63 |
| Issue | 9 | Pages | 3678-82 |
| PubMed ID | 2760978 | Mgi Jnum | J:9924 |
| Mgi Id | MGI:58381 | Doi | 10.1128/jvi.63.9.3678-3682.1989 |
| Citation | Regnier DC, et al. (1989) Identification of two murine loci homologous to the v-cbl oncogene. J Virol 63(9):3678-82 |
| abstractText | The virally transduced oncogene v-cbl transforms fibroblasts in vitro and induces early B-cell-lineage lymphomas in vivo. A series of probes derived from a molecular clone of v-cbl were used to map related sequences in the mouse genome. Analyses of Chinese hamster x mouse somatic-cell hybrids showed that two related genes, cbl-1 and cbl-2, were located on chromosomes 6 and 9, respectively. Restriction enzyme studies of DNA from hybrid cells containing either chromosome 6 or 9 suggested that cbl-1 resembles v-cbl and may be a processed gene, whereas cbl-2 has a complex genomic structure. Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1. |
