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Publication : Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6.

First Author  Bibbins KB Year  1989
Journal  Genomics Volume  5
Issue  1 Pages  139-43
PubMed ID  2767684 Mgi Jnum  J:9960
Mgi Id  MGI:58417 Doi  10.1016/0888-7543(89)90098-0
Citation  Bibbins KB, et al. (1989) Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. Genomics 5(1):139-43
abstractText  Our laboratory has recently cloned and characterized two testes-expressed loci--the Tcp-10 gene family cluster and the D17Si11 gene--that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.
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