| First Author | Laatikainen A | Year | 1989 |
| Journal | Scand J Immunol | Volume | 30 |
| Issue | 4 | Pages | 449-55 |
| PubMed ID | 2510290 | Mgi Jnum | J:27277 |
| Mgi Id | MGI:74694 | Doi | 10.1111/j.1365-3083.1989.tb02449.x |
| Citation | Laatikainen A (1989) Immune response against P815X2 mastocytoma growing in syngeneic DBA/2 mice. VI. Histamine-induced suppression of in vitro generation of tumour-specific cytotoxic T cells. Scand J Immunol 30(4):449-55 |
| abstractText | Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. The sensitivity of the spleen cells from P815X2 mastocytoma-bearing DBA/2 mice to histamine-induced suppression changed during tumour progression; by the time of cytotoxic peak reaction (between days 12 and 16 after P815X2 inoculation), the spleen cells were more resistant to histamine than the spleen cells obtained from mice a few days before or a few days after maximal cytotoxicity. Histamine had no effect on the effector function of in-vitro-generated cytotoxicity. The results suggest histamine-induced modulation of cytotoxic T-cell reactions in P815X2-bearing mice. |
