| First Author | Kingsmore SF | Year | 1989 |
| Journal | EMBO J | Volume | 8 |
| Issue | 13 | Pages | 4073-80 |
| PubMed ID | 2591369 | Mgi Jnum | J:10129 |
| Mgi Id | MGI:58585 | Doi | 10.1002/j.1460-2075.1989.tb08591.x |
| Citation | Kingsmore SF, et al. (1989) A 6000 kb segment of chromosome 1 is conserved in human and mouse. EMBO J 8(13):4073-80 |
| abstractText | A murine linkage map generated from analyses of 428 meiotic events in an interspecific cross and pulsed field gel electrophoresis allowed examination of the genomic organization of a 6000 kb segment of mouse and human chromosome 1. Analysis of five genes within this syntenic segment of both species revealed striking conservation of gene order, intergenic distance and, to a lesser extent, CpG dinucleotides. In the mouse, meiotic crossover events were not evenly distributed; a hot spot for meiotic recombination was coincident with a CpG-island. These studies provide a practical approach to aid physical mapping of the human genome and a model for determining the molecular principles that govern meiotic recombination. In addition, these findings demonstrate profound conservation of genomic organization over mammalian evolution. |
