| First Author | Ymer S | Year | 1989 |
| Journal | FEBS Lett | Volume | 258 |
| Issue | 1 | Pages | 119-22 |
| PubMed ID | 2556293 | Mgi Jnum | J:43551 |
| Mgi Id | MGI:1099728 | Doi | 10.1016/0014-5793(89)81630-8 |
| Citation | Ymer S, et al. (1989) Sequence and expression of a novel GABAA receptor alpha subunit. FEBS Lett 258(1):119-22 |
| abstractText | Cloned cDNA encoding the bovine alpha 4 subunit of the GABAA receptor has been isolated. The predicted 51 amino acid long mature protein contains an exceptionally long intracellular domain and shares 53-56% sequence similarity to the previously characterized alpha 1, alpha 2 and alpha 3 subunits. Co-expression of alpha 4 and beta 1 in Xenopus oocytes resulted in the formation of GABA-gated chloride channels with expected pharmacology, although no benzodiazepine potentiation was observed. Northern analysis indicates that a 4 kb alpha 4 mRNA is expressed in the calf cerebellum, cortex and hippocampus but is barely detectable in the rat brain. |
