| First Author | Garchon HJ | Year | 1989 |
| Journal | Nucleic Acids Res | Volume | 17 |
| Issue | 23 | Pages | 9871-88 |
| PubMed ID | 2602144 | Mgi Jnum | J:4487 |
| Mgi Id | MGI:52976 | Doi | 10.1093/nar/17.23.9871 |
| Citation | Garchon HJ, et al. (1989) The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes. Nucleic Acids Res 17(23):9871-88 |
| abstractText | The XLR sequence family encodes RNA transcripts specific to late-stage T and B cells and their neoplasms. Only one apparently functional mRNA has been identified thus far and this encodes a novel 25 kDa nuclear protein. In this report, we find that the XLR gene family is composed of 50-75 copies per haploid genome which localize to at least two different portions of the mouse X chromosome. Neither of these locations are near the xid mutation that earlier work had correlated with XLR. In addition, some members of this family are also on the Y chromosome. Another surprising finding is that while the fourteen genomic clones examined to date have the same exon-intron structure and are closely related with respect to sequence conservation (90%), all appear (in most cases by multiple criteria) to be non-functional, raising the possibility that all but one of the members of this large semi-dispersed family are pseudogenes. |
