| First Author | Eisenberg SP | Year | 1990 |
| Journal | Nature | Volume | 343 |
| Issue | 6256 | Pages | 341-6 |
| PubMed ID | 2137201 | Mgi Jnum | J:14587 |
| Mgi Id | MGI:62751 | Doi | 10.1038/343341a0 |
| Citation | Eisenberg SP, et al. (1990) Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343(6256):341-6 |
| abstractText | Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-1 beta. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity. |
