| First Author | Kamps MP | Year | 1990 |
| Journal | Cell | Volume | 60 |
| Issue | 4 | Pages | 547-55 |
| PubMed ID | 1967983 | Mgi Jnum | J:13147 |
| Mgi Id | MGI:61355 | Doi | 10.1016/0092-8674(90)90658-2 |
| Citation | Kamps MP, et al. (1990) A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60(4):547-55 |
| abstractText | It was previously shown that the chromosome 19 breakpoint of the t(1;19)(q23;p13.3) translocation, found in human pre-B cell acute lymphoblastic leukemias, is within the E2A transcription factor gene on chromosome 19. A cell line with this translocation contains two novel chimeric mRNAs, both with the same 5'E2A sequences but with different lengths of 3' sequence from a previously unrecognized gene dubbed prl, located on chromosome 1. The chimeric RNAs encode a protein that lacks 171 amino acids of E2A, including its DNA binding and dimerization motifs, but have instead a homeobox-related sequence from prl. Therefore, the production of a chimeric E2A-Prl protein may contribute to the acute lymphoblastic phenotype by directly altering the expression of genes normally responsive to the Prl homeoprotein. |
