| First Author | Nakamura T | Year | 1990 |
| Journal | Science | Volume | 247 |
| Issue | 4944 | Pages | 836-8 |
| PubMed ID | 2106159 | Mgi Jnum | J:16356 |
| Mgi Id | MGI:64437 | Doi | 10.1126/science.2106159 |
| Citation | Nakamura T, et al. (1990) Activin-binding protein from rat ovary is follistatin. Science 247(4944):836-8 |
| abstractText | Activin, a member of the transforming growth factor beta protein family, was originally isolated from gonadal fluids and stimulates the release of pituitary follicle-stimulating hormone (FSH). Activin has numerous functions in both normal and neoplastic cells. Various cells synthesize activin and have a specific binding site for this peptide. However, the molecular basis for its actions is unknown. A binding protein for activin was purified from rat ovary and was identical to follistatin, a specific inhibitor of FSH release. It is likely that the binding protein participates in the diverse regulatory actions of activin. |
