| First Author | Sim GK | Year | 1990 |
| Journal | Cell | Volume | 61 |
| Issue | 3 | Pages | 397-405 |
| PubMed ID | 2110506 | Mgi Jnum | J:30915 |
| Mgi Id | MGI:78199 | Doi | 10.1016/0092-8674(90)90522-g |
| Citation | Sim GK, et al. (1990) Dominantly inherited expression of BID, an invariant undiversified T cell receptor delta chain. Cell 61(3):397-405 |
| abstractText | In BALB/c lung and lymph node gamma delta T cells, a large fraction of the expressed V delta 5 genes consist of an invariant sequence, BID (for BALB/c invariant delta). BID results from a direct joining of the V delta 5, D delta 2, and J delta 1 segments, which conserve their complete germline coding sequences. In C57BL/6 (H-2b) mice, where identical and functional segments are present in the germline, BID is absent. It appears that BID+ gamma delta T cells are positively selected by factors encoded outside of the classical MHC region, as indicated by their dominance in F1(C57BL/6 x BALB/c) and in BALB.B (H-2b) mice. Additional observations, including the expression of BID in BALB/c nu/nu but not in C57BL/6 nu/nu mice, suggest that the expansion of BID+ T cells essentially occurs extrathymically. |
