| First Author | Jongeneel CV | Year | 1990 |
| Journal | J Exp Med | Volume | 171 |
| Issue | 6 | Pages | 2141-6 |
| PubMed ID | 2351934 | Mgi Jnum | J:10553 |
| Mgi Id | MGI:59001 | Doi | 10.1084/jem.171.6.2141 |
| Citation | Jongeneel CV, et al. (1990) A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain. J Exp Med 171(6):2141-6 |
| abstractText | We have amplified a (CA)n:(GT)n microsatellite from the TNF promoters of a panel of mouse strains using the polymerase chain reaction. The length of the microsatellites was polymorphic, with eight alleles observed among 15 inbred strains bearing seven distinct H-2 haplotypes, and four outbred strains. In B10 congenic strains, the TNF allele detected by microsatellite polymorphism segregated with the MHC, and in recombinant haplotypes (NOD, NZW), it segregated with H-2D. The TNF allele found in the NZW strain (H-2z) was distinct from those of all other haplotypes, consistent with the hypothesis that this strain may carry a genetic defect in TNF production. |
