| First Author | Jouvin-Marche E | Year | 1990 |
| Journal | EMBO J | Volume | 9 |
| Issue | 7 | Pages | 2141-50 |
| PubMed ID | 2357962 | Mgi Jnum | J:10567 |
| Mgi Id | MGI:59015 | Doi | 10.1002/j.1460-2075.1990.tb07383.x |
| Citation | Jouvin-Marche E, et al. (1990) Genomic organization of the mouse T cell receptor V alpha family. EMBO J 9(7):2141-50 |
| abstractText | Based on the analysis of V alpha gene segment deletions in a panel of T lymphomas, we have constructed a map of the mouse T cell receptor alpha/delta region and assigned the relative position of 72 distinct V gene segments. Three major observations have emerged from such studies. First, members of a given V alpha subfamily are not organized in discrete units along the chromosome but largely interspersed with members of other V alpha subfamilies. Second, analysis of the deletion map suggests the existence of repetitive patterns (V alpha clusters) in the chromosomal distribution of the V alpha gene segments. Third, the present-day organization of the V alpha/delta region may be readily explained by a series of sequential duplications involving three ancestral V alpha clusters. Direct evidence for the existence of these unique structural features has been gained by cloning approximately 370 kb of DNA and positioning 26 distinct V alpha gene segments belonging to six different subfamilies. Finally, the relationships existing between the V alpha/delta gene segment organization and usage are discussed in terms of position-dependent models. |
