| First Author | Müller B | Year | 1990 |
| Journal | Eur J Immunol | Volume | 20 |
| Issue | 6 | Pages | 1409-11 |
| PubMed ID | 2115001 | Mgi Jnum | J:10628 |
| Mgi Id | MGI:59076 | Doi | 10.1002/eji.1830200631 |
| Citation | Muller B, et al. (1990) A physical map and analysis of the murine C kappa-RS region show the presence of a conserved element. Eur J Immunol 20(6):1409-11 |
| abstractText | Lambda-producing B lymphocytes have frequently deleted one or, more often, both Ig kappa loci. This deletion is mediated by the rearrangement of an element which lies 3' of C kappa and which is called RS (recombining sequence) in the mouse and Kde (kappa-deleting element) in the human. The tight correlation between V lambda to J lambda rearrangements and an RS-mediated deletion may indicate that sequences in the C kappa-RS region are controlling the activation of the Ig lambda locus. We have linked the C kappa exon and the RS element by phage cloning and compared the C kappa-RS region to the previously cloned human C kappa-Kde region. The distance between C kappa and RS is 25 kb and is thus similar to the distance of 24 kb separating the human C kappa exon and Kde element. Both mouse and man carry a conserved sequence of 470 bp (Rx) which lies 9 kb 3' of the mouse C kappa and 12 kb 3' of the human C kappa exon. The conserved mouse Rx sequence contains part of the kappa 3' enhancer. |
