| First Author | Sinclair AH | Year | 1990 |
| Journal | Nature | Volume | 346 |
| Issue | 6281 | Pages | 240-4 |
| PubMed ID | 1695712 | Mgi Jnum | J:19152 |
| Mgi Id | MGI:67345 | Doi | 10.1038/346240a0 |
| Citation | Sinclair AH, et al. (1990) A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif [see comments]. Nature 346(6281):240-4 |
| abstractText | A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF. |
