| First Author | Buckle VJ | Year | 1989 |
| Journal | Neuron | Volume | 3 |
| Issue | 5 | Pages | 647-54 |
| PubMed ID | 2561974 | Mgi Jnum | J:23686 |
| Mgi Id | MGI:71557 | Doi | 10.1016/0896-6273(89)90275-4 |
| Citation | Buckle VJ, et al. (1989) Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron 3(5):647-54 |
| abstractText | Hybridization of GABAA receptor probes to human chromosomes in situ and to DNA from sorted human chromosomes has localized the genes encoding a beta subunit and three isoforms of the alpha subunit. The alpha 2 and beta genes are both located on chromosome 4 in bands p12-p13 and may be adjacent. The alpha 1 gene is on chromosome 5 (bands q34-q35) and the alpha 3 gene is on the X chromosome. The alpha 3 locus was mapped also on the mouse X chromosome using genetic break-point analysis in an interspecies pedigree. The combined results locate the human alpha 3 gene within band Xq28, in a location that makes it a candidate gene for the X-linked form of manic depression. |
