| First Author | Ohno S | Year | 1990 |
| Journal | Cytogenet Cell Genet | Volume | 53 |
| Issue | 4 | Pages | 225-9 |
| PubMed ID | 2209092 | Mgi Jnum | J:10758 |
| Mgi Id | MGI:59204 | Doi | 10.1159/000132937 |
| Citation | Ohno S, et al. (1990) Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet 53(4):225-9 |
| abstractText | Calcium dependent proteases (calpains, CAPNs, E.C.3.4.22.17) constitute a family of proteins which share a homologous cysteine-protease domain (large subunits, L1, L2, and L3) and an E-F hand Ca2(+)-binding domain (L1, L2, L3, and small subunit, S). We have mapped the genes for four calpain proteins (L1, L2, L3, and S) on four distinct human chromosomes by a combination of spot-blot hybridization to flow-sorted chromosomes and Southern hybridization of DNAs from a human x mouse hybrid cell panel. The genes for calpain L1 (CAPN1, large subunit of calpain I), L2 (CAPN2, large subunit of calpain II), L3 (CAPN3, a protein related to the large subunits), and S (CAPN4, a small subunit common to calpains I and II) were assigned to human chromosomes 11, 1, 15, and 19, respectively. |
