| First Author | Brunnert SR | Year | 1990 |
| Journal | Lab Anim Sci | Volume | 40 |
| Issue | 6 | Pages | 616-9 |
| PubMed ID | 2172626 | Mgi Jnum | J:25813 |
| Mgi Id | MGI:73537 | Citation | Brunnert SR, et al. (1990) Dystrophic cardiac calcinosis in mice: abnormal myocardial response to freeze-thaw injury. Lab Anim Sci 40(6):616-9 |
| abstractText | Dystrophic cardiac calcinosis (DCC) is a frequent finding in DBA/2, C3H and BALB/c mice and its etiology is not known. Previous studies have speculated that myocardial necrosis is involved in the pathogenesis of DCC. In this study, cardiac necrosis was induced in DBA/2, C3H and C57BL/6 mice by freeze-thaw injury through the abdominal diaphragm. Four weeks after freeze-thawing, the mice were sacrificed and the hearts and diaphragms were examined. In response to injury, cardiac mineralization was present only in DBA/2 and C3H mice. The myocardium of C57BL/6 mice (control strain) healed by fibrosis without mineralization, the normal response of the myocardium to injury. Calcified diaphragms also were present at the site of freeze-thaw injury in DBA/2 and C3H mice, which is supportive evidence that a systemic abnormality is involved in the pathogenesis of DCC. The conclusion from this study is that the pathogenesis of DCC in DBA/2 and C3H mice is multifactorial and involves both myocardial necrosis and an abnormal response to injury. |
