| First Author | Gilliam DM | Year | 1990 |
| Journal | Alcohol | Volume | 7 |
| Issue | 6 | Pages | 483-7 |
| PubMed ID | 2261084 | Mgi Jnum | J:45510 |
| Mgi Id | MGI:1195542 | Doi | 10.1016/0741-8329(90)90036-c |
| Citation | Gilliam DM, et al. (1990) Alcohol-related birth defects in long- and short-sleep mice: postnatal litter mortality. Alcohol 7(6):483-7 |
| abstractText | Alcohol sensitivity may influence the severity of alcohol-related birth defects (ARBD). To examine this hypothesis, pregnancy outcome and offspring development were examined in alcohol-sensitive Long-Sleep (LS) mice and alcohol-resistant Short-Sleep (SS) mice following prenatal ethanol exposure. Dams were intragastrically intubated twice per day (6 hr apart) with either 4.5 g/kg (20% w/v) ethanol (E) or an isocaloric amount of sucrose (S) on days 7 through 18 of pregnancy. An untreated control group (C) was maintained for each line. Results showed litter mortality at 10 days of age was greater for LS-E litters compared to both LS-S and LS-C litters. Litter mortality for SS-E litters did not differ from either SS-S or SS-C litters. Maternal weight gain, blood ethanol levels, and birth weight deficits were similar for ethanol-exposed LS and SS groups. These results suggest genetically based alcohol sensitivity influences the severity of ARBD. |
