| First Author | Macadam GC | Year | 1990 |
| Journal | Int J Biochem | Volume | 22 |
| Issue | 9 | Pages | 989-96 |
| PubMed ID | 2282966 | Mgi Jnum | J:27840 |
| Mgi Id | MGI:75476 | Doi | 10.1016/0020-711x(90)90205-h |
| Citation | Macadam GC, et al. (1990) A cryptic meprin-like proteolytic activity in mouse kidney brush border membranes. Int J Biochem 22(9):989-96 |
| abstractText | 1. Inbred mouse strains differ markedly in the expression of a kidney brush border metalloendopeptidase, meprin-a. 2. Brush border preparations from mice of the low-meprin-a phenotype (specific activities less than 5% of the high-meprin-a trait) contain a metallo-endopeptidase, meprin-b, that is larger than meprin-a, and which is inactive unless the membrane preparations are treated with trypsin. 3. This cryptic metallo-endopeptidase has been previously postulated to be a stalled precursor of phenotypes--and that this activity is similar in substrate specificity and amount present in the brush border. 5. Meprin-b may therefore be a distinct gene product that is independent of meprin-a phenotype. |
