| First Author | Gardner MB | Year | 1991 |
| Journal | Trends Genet | Volume | 7 |
| Issue | 1 | Pages | 22-7 |
| PubMed ID | 1848377 | Mgi Jnum | J:23548 |
| Mgi Id | MGI:71348 | Doi | 10.1016/0168-9525(91)90017-k |
| Citation | Gardner MB, et al. (1991) The Lake Casitas wild mouse: evolving genetic resistance to retroviral disease. Trends Genet 7(1):22-7 |
| abstractText | A small colony of feral mice from California continues to flourish in spite of a virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease. |
