| First Author | Hibino Y | Year | 1991 |
| Journal | J Biol Chem | Volume | 266 |
| Issue | 11 | Pages | 6948-51 |
| PubMed ID | 1826681 | Mgi Jnum | J:11127 |
| Mgi Id | MGI:59569 | Doi | 10.1016/s0021-9258(20)89594-5 |
| Citation | Hibino Y, et al. (1991) Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor. J Biol Chem 266(11):6948-51 |
| abstractText | In order to localize the chromosome encoding the accessory factor required for function of the murine interferon gamma (IFN-gamma) receptor, we transfected a cDNA expression vector encoding the receptor into several Chinese hamster x mouse somatic cell hybrids. As mouse Chromosome 10 carries the gene which encodes the interferon gamma-receptor (Ifgr), we used somatic cell hybrids that lack this chromosome. The presence of mouse Chromosome 16 was required to generate a response to murine IFN-gamma as assayed by stimulation of class I major histocompatibility complex antigen expression. These results demonstrate a species-specific accessory factor encoded on mouse Chromosome 16 (termed Ifgt) is necessary for mouse IFN-gamma to stimulate major histocompatibility complex expression through its receptor. |
