| First Author | Morris SW | Year | 1991 |
| Journal | Blood | Volume | 78 |
| Issue | 8 | Pages | 2013-20 |
| PubMed ID | 1912583 | Mgi Jnum | J:12670 |
| Mgi Id | MGI:59885 | Doi | 10.1182/blood.v78.8.2013.bloodjournal7882013 |
| Citation | Morris SW, et al. (1991) Reassignment of the human CSF1 gene to chromosome 1p13-p21. Blood 78(8):2013-20 |
| abstractText | Human macrophage colony-stimulating factor (CSF-1 or M-CSF) is encoded by a single gene that was previously assigned to the long arm of chromosome 5, band q33.1, in a region adjacent to the gene encoding its receptor (Pettenati MJ, et al, Proc Natl Acad Sci USA 84:2970, 1987). Using fluorescence in situ hybridization with genomic probes to examine normal metaphase chromosomes, we reassigned the human CSF1 gene to the short arm of chromosome 1, bands p13-p21. We confirmed this result by hybridizing a CSF1 cDNA probe to filters containing flow-sorted chromosomes and by identifying CSF1 sequences in DNAs extracted from human x rodent somatic cell hybrids that contained human chromosome 1 but not human chromosome 5. Our findings are consistent with studies that have shown tight linkage between the murine CSF1 and amylase genes, as part of a conserved linkage group between mouse chromosome 3 and the short arm of human chromosome 1, which also includes the genes encoding the beta subunits of thyrotropin and nerve growth factor. Assignment of the CSF1 gene to chromosome 1 at bands p13-p21 raises the possibility that it may be altered by certain nonrandom chromosomal abnormalities arising in human hematopoietic malignancies and solid tumors. |
