| First Author | Wisden W | Year | 1991 |
| Journal | FEBS Lett | Volume | 289 |
| Issue | 2 | Pages | 227-30 |
| PubMed ID | 1655526 | Mgi Jnum | J:43107 |
| Mgi Id | MGI:1099737 | Doi | 10.1016/0014-5793(91)81076-k |
| Citation | Wisden W, et al. (1991) Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit. FEBS Lett 289(2):227-30 |
| abstractText | A cDNA of rat brain encoding the GABAA receptor alpha 4 subunit has been cloned. Recombinant receptors composed of alpha 4, beta 2 and gamma 2 subunit bind with high affinity the GABA agonist [3H]muscimol and the benzodiazepine 'alcohol antagonist' [3H]Ro 15-4513, but fail to bind benzodiazepine agonists. The alpha 4 subunit is expressed mainly in the thalamus, as assessed by in situ hybridization histochemistry, and may participate in a major population of thalamic GABAA receptors. The alpha 4 mRNA is found at lower levels in cortex and caudate putamen, and is rare in cerebellum. |
