| First Author | Itoh S | Year | 1991 |
| Journal | Genomics | Volume | 10 |
| Issue | 4 | Pages | 1097-9 |
| PubMed ID | 1680796 | Mgi Jnum | J:11479 |
| Mgi Id | MGI:59912 | Doi | 10.1016/0888-7543(91)90208-v |
| Citation | Itoh S, et al. (1991) Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31. Genomics 10(4):1097-9 |
| abstractText | It has been shown that a nuclear factor, interferon regulatory factor-1 (IRF1), plays a key role in the regulation of the type I interferon (IFN) system by affecting the transcription of type I IFN and some IFN-inducible genes. In this study, the human IRF1 gene was mapped to chromosome 5 by analysis of mouse-human somatic cell hybrids. Furthermore, by linkage analysis based on RFLP (restriction fragment length polymorphism), the gene was localized to chromosome 5q23-q31, the region that has been termed critical for some myeloid disorders. |
