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Publication : A dominant negative form of transcription activator mTFE3 created by differential splicing.

First Author  Roman C Year  1991
Journal  Science Volume  254
Issue  5028 Pages  94-7
PubMed ID  1840705 Mgi Jnum  J:29571
Mgi Id  MGI:77102 Doi  10.1126/science.1840705
Citation  Roman C, et al. (1991) A dominant negative form of transcription activator mTFE3 created by differential splicing. Science 254(5028):94-7
abstractText  Transcription factor E3 (mTFE3) is a murine transcription activator that binds to the intronic enhancer of the immunoglobulin heavy chain gene. A naturally occurring splice product of mTFE3 messenger RNA (mRNA) lacked 105 nucleotides that encode an activation domain; both absolute and relative amounts of long and truncated mRNAs varied in different tissues. Cells were cotransfected with complementary DNAs that encoded the two mRNA forms in amounts that corresponded to the amounts of each mRNA found in different cells. Small changes in substoichiometric amounts of the truncated form of mRNA effected trans-dominant negative modulation of mTFE3 activity. These findings identify a function for differential splicing in the regulation of transcription factor activity.
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