| First Author | Müller G | Year | 1991 |
| Journal | Hum Genet | Volume | 88 |
| Issue | 1 | Pages | 59-63 |
| PubMed ID | 1683646 | Mgi Jnum | J:403 |
| Mgi Id | MGI:48940 | Doi | 10.1007/BF00204930 |
| Citation | Muller G, et al. (1991) Comparative mapping of ZFY in the hominoid apes. Hum Genet 88(1):59-63 |
| abstractText | Within our project of comparative mapping of candidate genes for sex-determination/testis differentiation, we used a cloned probe from the human ZFY locus for comparative hybridization studies in hominoids. As in the human, the ZFY probe detects X- and Y-specific restriction fragments in the chimpanzee, the gorilla, the orangutan, and the gibbon. Furthermore, the X-specific hybridization site in the great apes resides in Xp21.3, the same locus defining ZFX in the human. The Y-specific locus of ZFY maps closely to the early replicating pseudoautosomal segment in the telomeric or subtelomeric position of the Y chromosomes of the great apes, again as found in the human. Thus, despite cytogenetically visible structural alterations within the euchromatic parts of the Y chromosomes of the human species and the great apes, a segment of the Y chromosome defined by the pseudoautosomal region and ZFY seems to be more strongly conserved than the rest of the Y chromosome. |
