| First Author | Milatovich A | Year | 1991 |
| Journal | Somat Cell Mol Genet | Volume | 17 |
| Issue | 5 | Pages | 519-23 |
| PubMed ID | 1662415 | Mgi Jnum | J:399 |
| Mgi Id | MGI:48936 | Doi | 10.1007/BF01233176 |
| Citation | Milatovich A, et al. (1991) Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet 17(5):519-23 |
| abstractText | Tumor necrosis factor, TNF, is a 17-kDa protein secreted by macrophages and classified as a cytokine. TNF binds to high-affinity receptors on the cell surface and is involved in a wide variety of biological responses. There are at least two types of receptors, tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2). The genes for TNFR1 a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 1 12 (12pter-cen) and (1pter-p32), respectively, by Southern blot analysis of human x Chinese hamster somatic cell hybrid panels. Recently, the corresponding genes in the mouse have been mapped to chromosomes 4 and 6 in regions that are conserved on human chromosomes 1 and 12. |
