| First Author | Yang-Feng TL | Year | 1991 |
| Journal | Nucleic Acids Res | Volume | 19 |
| Issue | 25 | Pages | 7125-9 |
| PubMed ID | 1766873 | Mgi Jnum | J:2617 |
| Mgi Id | MGI:51139 | Doi | 10.1093/nar/19.25.7125 |
| Citation | Yang-Feng TL, et al. (1991) Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res 19(25):7125-9 |
| abstractText | The human serine/threonine protein casein kinase II (CK II) contains two distinct catalytic subunits, alpha and alpha 1, which are encoded by different genes. A combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization have localized the human CK II-alpha DNA sequence to two loci: 11p15.5-p15.4 and 20p13. In contrast, the CK II-alpha' gene has been mapped to chromosome 16 by somatic cell hybrid analysis. Taken together with our previous assignment of the CK II regulatory beta-subunit gene to 6p12-p21, these results indicate that although the products of these genes form a single biological complex, they are encoded on different human chromosomes. Further analysis should determine whether both loci of CK II-alpha are functional, or perhaps one of the two constitutes a pseudogene. |
