| First Author | Chin HM | Year | 1991 |
| Journal | Genomics | Volume | 11 |
| Issue | 4 | Pages | 914-9 |
| PubMed ID | 1664412 | Mgi Jnum | J:1538 |
| Mgi Id | MGI:50065 | Doi | 10.1016/0888-7543(91)90014-6 |
| Citation | Chin HM, et al. (1991) A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3. Genomics 11(4):914-9 |
| abstractText | A rat brain cDNA probe was used to localize a gene encoding the alpha 1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster x mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel alpha 1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14. |
