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Publication : Expression of the dystrophin gene in mouse and rat brain.

First Author  Gorecki D Year  1991
Journal  Neuroreport Volume  2
Issue  12 Pages  773-6
PubMed ID  1793820 Mgi Jnum  J:1022
Mgi Id  MGI:49554 Doi  10.1097/00001756-199112000-00011
Citation  Gorecki D, et al. (1991) Expression of the dystrophin gene in mouse and rat brain. Neuroreport 2(12):773-6
abstractText  Duchenne muscular dystrophy is due to mutations in the dystrophin gene which is predominantly expressed in muscle and brain. Since the disease is associated with cognitive impairment, we sought to localize dystrophin mRNA in brain using in situ hybridization with oligonucleotide probes. We find the gene strongly expressed in the hippocampus and cerebral cortex, areas with an established cognitive function, and also in the Purkinje cells of the cerebellum, an area associated with motor coordination.
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